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KMID : 0362320100350040295
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Journal of Korean Academy of Operative Dentistry
2010 Volume.35 No. 4 p.295 ~ p.301
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ANALYSIS OF PARA-CHLOROANILINE AFTER CHEMICAL INTERACTION BETWEEN ALEXIDINE AND SODIUM HYPOCHLORITE USING MASS SPECTROMETRY
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Kim Hyeon-Sik
Han Seung-Hyun
Oh So-Ram
Lim Sang-Min
Gu Yu
Kum Kee-Yeon
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Abstract
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Recent studies demonstrated that the combination of chlorhexidine (CHX) and sodium hypochlorite (NaOCl) resulted in the formation of a precipitate, para-chloroaniline (PCA). Alexdidine (ALX) is a kind of biguanides like CHX, and has stronger detoxification effect against the bacterial virulence factors such as lipoteichoic acid and lipopolysacchardide compared with CHX. The purpose of this study was to determine whether PCA was formed after chemical interaction between ALX and NaOCl using mass spectrometry. Mass spectrometry was performed for the mixture of five different concentrations of ALX (1, 0.5, 0.25, 0.125, 0.0625%) and 4% NaOCl. Results showed that the peak of PCA was not detected in mixed solutions of ALX and NaOCl in mass spectrometry analysis. The color of mixed solution of ALX and NaOCl after chemical interaction was light yellow to white, but there wasn’t any precipitate found.
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KEYWORD
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Alexidine, Chemical interaction, Mass spectrometry, Para-chloroaniline, Sodium hypochlorite
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